Post Cycle Therapy

How Does Tamoxifen Work?

Tamoxifen is the main ingredient in the brand Nolvadex (sold as other brand names too) and is an orally active drug classified as an anti cancer drug in medical settings as is approved by FDA for preventing breast cancer in women and treating breast cancer in men and women. It also has other uses such as the treatment of gynecomastia and others.


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Tamoxifen, therefore, is also an anti estrogen medication, exactly as Aromatase Inhibitors (AIs) such as Aromasin – Exemestane, Arimidex – Anastrozole, and Femara – Letrozole.

Nonetheless, there’s a huge difference in how AIs and SERMs work. We are going to talk about this here.

Tamoxifen Use in Bodybuilding

In the bodybuilding world, Tamoxifen has 2 main uses – either for gynecomastia treatment or prevention or mostly as a Post Cycle Therapy drug. This compound is effective in helping users of anabolic steroids to prevent the apparition of gynecomastia (formation of breast tissue) or for treating it in case it already appeared. It also helps people who get this condition naturally.

Bodybuilders find Tamoxifen Citrate (Nolvadex) highly effective when they run aromatized steroids that are converted into estrogen in the body.

Examples of such steroids: Dianabol and Testosterone are most popular but there are many others.

In such a situation, a user is likely to get high estrogen related side effects. For example blood pressure, erectile dysfunction, water retention and one of the most common estrogen related side effects – puffy nipples. It can lead to gynecomastia.

Tamoxifen is effective to deal with gynecomastia, but is not effective in dealing with other estrogen related side effects.

That’s why bodybuilders find AIs better for such needs. And they find Tamoxifen better for PCT plans.


How Does Tamoxifen Work For Gynecomastia Prevention?

Tamoxifen CitrateNolvadex is a SERM, therefore is selectively binding to estrogen receptors blocking their actions. Tamoxifen doesn’t bind to all estrogen receptors, but selectively and mainly – in breast tissues.

Therefore, Tamoxifen is not allowing active estrogen to “do its job”. This can lead to breast cancer and gynecomastia in men. That’s why the compound is run during the cycle with steroids. It would prevent this side effect from appearing.

Nonetheless, there is the option of running AIs which are actually reducing the total flow of estrogen in the body. It not only would block the estrogen from the receptor as Nolvadex does.

Therefore, AIs would help both with gynecomastia issues and with other estrogen related side effects too.

That’s why Nolvadex (Tamoxifen) is mostly used for PCT protocols.

How Does Tamoxifen Work For PCT?

When you run anabolic steroids, the body receives signals that too many hormones are produced so it stops producing them naturally. Depending on the type, amount, dosage of steroids as well as cycle length – there are different levels of suppression.


But any anabolic steroid cycle suppresses the production of testosterone that’s why it is important to run a PCT plan to help your body recover HPTA. Tamoxifen does exactly that.

Tamoxifen Citrate is stimulating the hypothalamus for releasing more gonadotropins – the protein hormones that are secreted by the pituitary gland which are responsible for a faster and higher release of FSH and LH. As a result, you get more testosterone since Tamoxifen helps increase LH.

Therefore, you are capable of getting a boosted testosterone level, a smooth PCT and won’t get typical symptoms of getting off a steroid cycle.

  • You won’t lose muscles, gain fat, lose energy, lose sex drive, motivation etc.

As mentioned, Tamoxifen selectively binds to estrogen receptors blocking their activity – that’s how it works here too. It prevents estrogen from reaching the pituitary gland and therefore, this leads to higher production of LH. The Luteinizing Hormone (LH) offers signals to the Leydig cells for producing testosterone.

Tamoxifen is extremely effective – studies prove that users of Tamoxifen who used to have LH levels of almost 0 – they managed to reach over 10 iu (through blood works, obviously) and that’s even more than the normal reference range for an adult man.

  • Keep in mind that Tamoxifen Citrate (Nolvadex) should be used to spike your testosterone temporarily and keep you from symptoms you may get from getting off a cycle. It helps boost the recovery process but after a while, you’ve got to let your body recover on its own.

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Customers are free to buy Tamoxifen for sale including any other compounds they may need (steroids, anti estrogens, AIs etc.) directly from

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