Letrozole (brand name Femara including many others) is an extremely powerful Anti Estrogenic medication. It is mostly used in emergency situations when estrogen should be controlled fast and efficiently by most bodybuilders and other anabolic steroid users.
This is an orally active Aromatase Inhibitor (AI). The product is known to lower total estrogen levels in circulation. In fact, is considered the most powerful aromatase inhibitor on the market.
Letrozole (Femara) is medically used for the treatment of hormonally responsive breast cancer in post-menopausal women. But it has other medical uses too. For example ovulation induction in women, sperm boost in men, gynecomastia treatment, and various others.
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- Nonetheless, Letrozole is a very popular product among those using anabolic steroids. That’s because it is known to quickly and sharply lower estrogen levels whenever is needed.
Letrozole Half Life and Explanation
The half life of Letrozole is considered to be 2-4 days. Therefore, the compound is going to be effective at keeping your estrogen levels lower for a while after the last dosage.
The compound, exactly as other AIs, tend to build up in the system so it requires a while until it would come in “full strength”.
Nonetheless, Letrozole is still known to work faster than other AIs as it can sharply lower down estrogens from the first administration.
Since Letrozole half life is 2-4 days, it would stay in your system for at least 4 days, up to 8 days. This depends from person to person. It has an extremely high bioavailability of 99.9%. It is being excreted from the body through the kidneys.
Keep in mind that it keeps estrogen levels low during its use, but Femara (Letrozole) is a non suicidal and non steroidal Aromatase Inhibitor (AI) which means that it doesn’t permanently disable aromatase enzymes as Exemestane does.
- Therefore, there’s a chance of “estrogen rebound” when stopping Letrozole.
That’s why you would love to continue administering Letrozole for a while after stopping the use of steroids and slowly reducing down the dosages.
Femara (Letrozole) is most commonly coming in the form of oral tablets of 2.5 mg strength.
That’s because this is the most commonly prescribed dosage to women suffering from hormonally positive breast cancer (the main purpose of using Letrozole medically).
However, 2.5 mg per day of Letrozole sounds way too much for anabolic steroid users. There’s rarely anyone who needs a higher dosage than 1 mg per day.
But is not uncommon for some men to run doses as low as 0.25 mg every other day.
In the end, the dosage of Letrozole, as much as you can notice, varies a lot. That’s because it depends on a number of factors. Such as you are trying to prevent estrogen related issues, or you are trying to treat an already occurring issue (such as gynecomastia) and use it as an emergency compound.
- It also depends on how prone you are to get estrogen related issues, how many steroids you use, their type, their dosage, for how long you’ve been running them, and so on and so forth.
Determining Letrozole dosage depends on a lot of factors. That’s why there are such huge differences in Letrozole doses.
But generally, dosages of 0.5 mg up to 1 mg per day or every other day are the most common ones.
Letrozole Side Effects
Generally, the side effects of Letrozole are very well tolerated by most men. They may not get any side effects at all as long as the compound is used properly.
Yet, some may still get them.
But because Letrozole has a half life of 2-4 days, it is believed that the side effects would quickly disappear as soon as you stop the administration of this AI. Just watch out for estrogen rebound.
- In the end, Letrozole side effects are associated with too high dosages and therefore, too low estrogen related issues. They usually include weakness, fatigue, low sex drive, painful and dry joints, and others.
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